異己(ji)(ji)(ji)二(er)(er)醇(chun)(chun)(chun)（通常指2-甲基(ji)-2，4-）在(zai)(zai)(zai)醫藥(yao)領域中(zhong)(zhong)的應(ying)(ying)(ying)用(yong)(yong)受(shou)到多(duo)重限制(zhi)(zhi)，主要涉(she)及(ji)(ji)毒性(xing)(xing)(xing)、穩(wen)定(ding)性(xing)(xing)(xing)、法規及(ji)(ji)成(cheng)(cheng)(cheng)本(ben)等因素，具(ju)體表現如(ru)下：###1.**毒性(xing)(xing)(xing)與(yu)(yu)(yu)(yu)(yu)安(an)(an)全性(xing)(xing)(xing)限制(zhi)(zhi)**異己(ji)(ji)(ji)二(er)(er)醇(chun)(chun)(chun)作為，盡管其(qi)(qi)(qi)急性(xing)(xing)(xing)毒性(xing)(xing)(xing)低于(yu)乙二(er)(er)醇(chun)(chun)(chun)（LD50約3.4g/kg，大鼠口服），但長期(qi)或(huo)(huo)高劑(ji)量使用(yong)(yong)仍可能(neng)(neng)(neng)引(yin)(yin)發(fa)健康風(feng)險。其(qi)(qi)(qi)代(dai)謝產(chan)物(wu)可能(neng)(neng)(neng)對肝造成(cheng)(cheng)(cheng)負擔(dan)，且局部應(ying)(ying)(ying)用(yong)(yong)時可能(neng)(neng)(neng)刺激黏膜或(huo)(huo)皮(pi)膚。在(zai)(zai)(zai)注射制(zhi)(zhi)劑(ji)中(zhong)(zhong)，高濃度可能(neng)(neng)(neng)引(yin)(yin)起溶血或(huo)(huo)組織(zhi)損(sun)傷，限制(zhi)(zhi)了(le)其(qi)(qi)(qi)在(zai)(zai)(zai)腸外給(gei)藥(yao)中(zhong)(zhong)的使用(yong)(yong)。此外，缺乏長期(qi)毒理(li)學(xue)(xue)數據使其(qi)(qi)(qi)在(zai)(zai)(zai)慢中(zhong)(zhong)的應(ying)(ying)(ying)用(yong)(yong)存疑。###2.**藥(yao)代(dai)動力學(xue)(xue)與(yu)(yu)(yu)(yu)(yu)蓄(xu)積(ji)風(feng)險**異己(ji)(ji)(ji)二(er)(er)醇(chun)(chun)(chun)的親脂性(xing)(xing)(xing)可能(neng)(neng)(neng)導致其(qi)(qi)(qi)在(zai)(zai)(zai)脂肪組織(zhi)中(zhong)(zhong)蓄(xu)積(ji)，尤其(qi)(qi)(qi)在(zai)(zai)(zai)不(bu)全患者中(zhong)(zhong)排泄減緩(huan)，增(zeng)(zeng)加毒性(xing)(xing)(xing)風(feng)險。代(dai)謝途徑不(bu)明確(que)也使得與(yu)(yu)(yu)(yu)(yu)其(qi)(qi)(qi)他(ta)的相互(hu)作用(yong)(yong)難以預(yu)測(ce)(ce)，可能(neng)(neng)(neng)影響(xiang)聯合用(yong)(yong)藥(yao)的安(an)(an)全性(xing)(xing)(xing)。###3.**配伍性(xing)(xing)(xing)與(yu)(yu)(yu)(yu)(yu)穩(wen)定(ding)性(xing)(xing)(xing)問(wen)題**作為輔(fu)料(liao)，阿克蘇異己(ji)(ji)(ji)二(er)(er)醇(chun)(chun)(chun)，異己(ji)(ji)(ji)二(er)(er)醇(chun)(chun)(chun)可能(neng)(neng)(neng)與(yu)(yu)(yu)(yu)(yu)某些活性(xing)(xing)(xing)成(cheng)(cheng)(cheng)分發(fa)生(sheng)化(hua)學(xue)(xue)反應(ying)(ying)(ying)，如(ru)與(yu)(yu)(yu)(yu)(yu)胺類發(fa)生(sheng)縮合或(huo)(huo)導致pH敏感型(xing)降解。其(qi)(qi)(qi)吸(xi)濕性(xing)(xing)(xing)可能(neng)(neng)(neng)影響(xiang)固體制(zhi)(zhi)劑(ji)的穩(wen)定(ding)性(xing)(xing)(xing)，需(xu)嚴格(ge)控濕環境，增(zeng)(zeng)加生(sheng)產(chan)成(cheng)(cheng)(cheng)本(ben)。###4.**法規與(yu)(yu)(yu)(yu)(yu)合規性(xing)(xing)(xing)挑戰(zhan)**多(duo)數國家藥(yao)典（如(ru)USP、EP）未將其(qi)(qi)(qi)列(lie)為標準藥(yao)用(yong)(yong)輔(fu)料(liao)，需(xu)額外進行安(an)(an)全性(xing)(xing)(xing)評估，延長新藥(yao)審批周期(qi)。環保法規對其(qi)(qi)(qi)生(sheng)產(chan)廢棄(qi)物(wu)的處理(li)要求也可能(neng)(neng)(neng)抬高合規成(cheng)(cheng)(cheng)本(ben)。###5.**成(cheng)(cheng)(cheng)本(ben)與(yu)(yu)(yu)(yu)(yu)替代(dai)品競爭**合成(cheng)(cheng)(cheng)異己(ji)(ji)(ji)二(er)(er)醇(chun)(chun)(chun)需(xu)多(duo)步反應(ying)(ying)(ying)，原料(liao)成(cheng)(cheng)(cheng)本(ben)較高，且純度要求嚴苛。相比之下，丙二(er)(er)醇(chun)(chun)(chun)、聚(ju)乙二(er)(er)醇(chun)(chun)(chun)等替代(dai)品具(ju)備更(geng)成(cheng)(cheng)(cheng)熟的藥(yao)用(yong)(yong)歷史(shi)、更(geng)低毒性(xing)(xing)(xing)及(ji)(ji)成(cheng)(cheng)(cheng)本(ben)優勢(shi)，擠壓了(le)異己(ji)(ji)(ji)二(er)(er)醇(chun)(chun)(chun)的應(ying)(ying)(ying)用(yong)(yong)空間。###6.**生(sheng)物(wu)相容(rong)性(xing)(xing)(xing)限制(zhi)(zhi)**在(zai)(zai)(zai)涂層或(huo)(huo)植入材料(liao)中(zhong)(zhong)，異己(ji)(ji)(ji)二(er)(er)醇(chun)(chun)(chun)可能(neng)(neng)(neng)引(yin)(yin)發(fa)局部反應(ying)(ying)(ying)，需(xu)通過(guo)(guo)ISO10993系(xi)列(lie)生(sheng)物(wu)相容(rong)性(xing)(xing)(xing)測(ce)(ce)試，進一(yi)步增(zeng)(zeng)加研發(fa)投(tou)入和時間成(cheng)(cheng)(cheng)本(ben)。綜上，異己(ji)(ji)(ji)二(er)(er)醇(chun)(chun)(chun)在(zai)(zai)(zai)醫藥(yao)領域的應(ying)(ying)(ying)用(yong)(yong)受(shou)限于(yu)安(an)(an)全性(xing)(xing)(xing)、穩(wen)定(ding)性(xing)(xing)(xing)及(ji)(ji)經濟性(xing)(xing)(xing)等多(duo)重因素，目前僅(jin)能(neng)(neng)(neng)在(zai)(zai)(zai)嚴格(ge)控制(zhi)(zhi)的低濃度局部制(zhi)(zhi)劑(ji)或(huo)(huo)特(te)定(ding)合成(cheng)(cheng)(cheng)工藝中(zhong)(zhong)作為過(guo)(guo)渡溶劑(ji)使用(yong)(yong)，未來(lai)需(xu)通過(guo)(guo)結構修飾或(huo)(huo)毒理(li)研究突破(po)才能(neng)(neng)(neng)拓(tuo)展其(qi)(qi)(qi)應(ying)(ying)(ying)用(yong)(yong)范圍。

異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)（如(ru)(ru)2，2，4-基(ji)-1，3-，簡(jian)稱TMPD）作(zuo)(zuo)為一類(lei)多(duo)(duo)元(yuan)醇(chun)(chun)(chun)(chun)(chun)(chun)類(lei)成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)助(zhu)劑(ji)(ji)(ji)，在(zai)涂(tu)(tu)料(liao)(liao)、膠黏(nian)劑(ji)(ji)(ji)等領域中(zhong)與(yu)其(qi)(qi)(qi)(qi)他(ta)常(chang)見成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)助(zhu)劑(ji)(ji)(ji)（如(ru)(ru)Texanol、丙二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)苯醚(mi)、乙(yi)(yi)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)丁(ding)醚(mi)等）相(xiang)(xiang)比，在(zai)成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)性(xing)(xing)(xing)(xing)(xing)(xing)能(neng)(neng)上存在(zai)顯著差異(yi)(yi)(yi)，主要(yao)體(ti)現(xian)在(zai)以下(xia)(xia)幾個方面：###1.**揮發速(su)率與(yu)成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)效(xiao)率**異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)的(de)(de)(de)(de)沸點通常(chang)在(zai)200℃以上（如(ru)(ru)TMPD沸點約214℃），異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)十(shi)年老品牌，屬于(yu)高(gao)(gao)(gao)沸點溶(rong)劑(ji)(ji)(ji)，異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)信譽可(ke)(ke)靠，揮發速(su)率較(jiao)(jiao)慢(man)。相(xiang)(xiang)較(jiao)(jiao)于(yu)低(di)(di)(di)(di)沸點助(zhu)劑(ji)(ji)(ji)（如(ru)(ru)乙(yi)(yi)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)丁(ding)醚(mi)，沸點171℃），異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)能(neng)(neng)延長(chang)涂(tu)(tu)膜(mo)(mo)(mo)(mo)的(de)(de)(de)(de)“開放時(shi)間”，使涂(tu)(tu)料(liao)(liao)在(zai)干燥過(guo)程中(zhong)更(geng)充分地流平，減少(shao)(shao)橘皮、縮(suo)孔(kong)等缺(que)陷。然而(er)，其(qi)(qi)(qi)(qi)緩(huan)慢(man)揮發可(ke)(ke)能(neng)(neng)在(zai)高(gao)(gao)(gao)濕度(du)或低(di)(di)(di)(di)溫(wen)環(huan)(huan)境(jing)中(zhong)導致干燥時(shi)間延長(chang)，需(xu)(xu)(xu)配(pei)合其(qi)(qi)(qi)(qi)他(ta)助(zhu)劑(ji)(ji)(ji)調整揮發梯度(du)。###2.**相(xiang)(xiang)容性(xing)(xing)(xing)(xing)(xing)(xing)與(yu)成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)均勻性(xing)(xing)(xing)(xing)(xing)(xing)**異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)與(yu)多(duo)(duo)種(zhong)樹脂(zhi)(zhi)體(ti)系（如(ru)(ru)、聚氨酯）的(de)(de)(de)(de)相(xiang)(xiang)容性(xing)(xing)(xing)(xing)(xing)(xing)較(jiao)(jiao)好(hao)，尤其(qi)(qi)(qi)(qi)在(zai)極(ji)性(xing)(xing)(xing)(xing)(xing)(xing)較(jiao)(jiao)高(gao)(gao)(gao)的(de)(de)(de)(de)水(shui)(shui)(shui)性(xing)(xing)(xing)(xing)(xing)(xing)體(ti)系中(zhong)表(biao)現(xian)優異(yi)(yi)(yi)。相(xiang)(xiang)較(jiao)(jiao)于(yu)Texanol（酯類(lei)成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)助(zhu)劑(ji)(ji)(ji)），異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)對(dui)疏水(shui)(shui)(shui)性(xing)(xing)(xing)(xing)(xing)(xing)樹脂(zhi)(zhi)的(de)(de)(de)(de)增塑作(zuo)(zuo)用(yong)較(jiao)(jiao)弱(ruo)，但(dan)能(neng)(neng)更(geng)均勻地分散于(yu)水(shui)(shui)(shui)性(xing)(xing)(xing)(xing)(xing)(xing)乳液中(zhong)，提升成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)致密性(xing)(xing)(xing)(xing)(xing)(xing)，減少(shao)(shao)因相(xiang)(xiang)分離導致的(de)(de)(de)(de)膜(mo)(mo)(mo)(mo)缺(que)陷。而(er)Texanol在(zai)溶(rong)劑(ji)(ji)(ji)型(xing)體(ti)系中(zhong)因強溶(rong)解力(li)更(geng)易形成(cheng)(cheng)(cheng)(cheng)均相(xiang)(xiang)膜(mo)(mo)(mo)(mo)。###3.**成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)后的(de)(de)(de)(de)物(wu)理性(xing)(xing)(xing)(xing)(xing)(xing)能(neng)(neng)**異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)作(zuo)(zuo)為小分子多(duo)(duo)元(yuan)醇(chun)(chun)(chun)(chun)(chun)(chun)，能(neng)(neng)夠(gou)有(you)效(xiao)降(jiang)低(di)(di)(di)(di)乳液的(de)(de)(de)(de)低(di)(di)(di)(di)成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)溫(wen)度(du)（MFFT），促進乳膠粒子融合，形成(cheng)(cheng)(cheng)(cheng)連續且柔(rou)(rou)韌(ren)的(de)(de)(de)(de)涂(tu)(tu)膜(mo)(mo)(mo)(mo)。與(yu)丙二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)苯醚(mi)（PPH）相(xiang)(xiang)比，異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)工廠，異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)賦(fu)予涂(tu)(tu)膜(mo)(mo)(mo)(mo)更(geng)高(gao)(gao)(gao)的(de)(de)(de)(de)韌(ren)性(xing)(xing)(xing)(xing)(xing)(xing)和(he)(he)耐擦洗性(xing)(xing)(xing)(xing)(xing)(xing)，但(dan)可(ke)(ke)能(neng)(neng)略微(wei)降(jiang)低(di)(di)(di)(di)硬度(du)。此外，其(qi)(qi)(qi)(qi)分子結構中(zhong)的(de)(de)(de)(de)多(duo)(duo)個羥基(ji)可(ke)(ke)增強涂(tu)(tu)膜(mo)(mo)(mo)(mo)與(yu)基(ji)材(cai)的(de)(de)(de)(de)附(fu)著力(li)，尤其(qi)(qi)(qi)(qi)在(zai)多(duo)(duo)孔(kong)表(biao)面（如(ru)(ru)木材(cai)）上表(biao)現(xian)突出。###4.**環(huan)(huan)保(bao)性(xing)(xing)(xing)(xing)(xing)(xing)與(yu)應(ying)用(yong)限制**異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)的(de)(de)(de)(de)VOC含量較(jiao)(jiao)低(di)(di)(di)(di)，符(fu)合環(huan)(huan)保(bao)趨勢，且毒性(xing)(xing)(xing)(xing)(xing)(xing)較(jiao)(jiao)傳統類(lei)助(zhu)劑(ji)(ji)(ji)更(geng)低(di)(di)(di)(di)。然而(er)，其(qi)(qi)(qi)(qi)水(shui)(shui)(shui)溶(rong)性(xing)(xing)(xing)(xing)(xing)(xing)較(jiao)(jiao)高(gao)(gao)(gao)（如(ru)(ru)TMPD在(zai)水(shui)(shui)(shui)中(zhong)溶(rong)解度(du)約4.5%），可(ke)(ke)能(neng)(neng)在(zai)高(gao)(gao)(gao)濕度(du)環(huan)(huan)境(jing)下(xia)(xia)影響(xiang)涂(tu)(tu)膜(mo)(mo)(mo)(mo)耐水(shui)(shui)(shui)性(xing)(xing)(xing)(xing)(xing)(xing)，需(xu)(xu)(xu)搭配(pei)疏水(shui)(shui)(shui)助(zhu)劑(ji)(ji)(ji)使用(yong)。相(xiang)(xiang)比之下(xia)(xia)，Texanol雖(sui)VOC較(jiao)(jiao)高(gao)(gao)(gao)，但(dan)疏水(shui)(shui)(shui)性(xing)(xing)(xing)(xing)(xing)(xing)極(ji)強，耐水(shui)(shui)(shui)性(xing)(xing)(xing)(xing)(xing)(xing)能(neng)(neng)更(geng)優。###5.**成(cheng)(cheng)(cheng)(cheng)本與(yu)適(shi)(shi)用(yong)范(fan)圍**異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)的(de)(de)(de)(de)生產成(cheng)(cheng)(cheng)(cheng)本通常(chang)高(gao)(gao)(gao)于(yu)乙(yi)(yi)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)醚(mi)類(lei)助(zhu)劑(ji)(ji)(ji)，但(dan)低(di)(di)(di)(di)于(yu)Texanol。其(qi)(qi)(qi)(qi)綜(zong)合性(xing)(xing)(xing)(xing)(xing)(xing)能(neng)(neng)使其(qi)(qi)(qi)(qi)更(geng)適(shi)(shi)用(yong)于(yu)對(dui)涂(tu)(tu)膜(mo)(mo)(mo)(mo)柔(rou)(rou)韌(ren)性(xing)(xing)(xing)(xing)(xing)(xing)和(he)(he)流平性(xing)(xing)(xing)(xing)(xing)(xing)要(yao)求(qiu)高(gao)(gao)(gao)的(de)(de)(de)(de)水(shui)(shui)(shui)性(xing)(xing)(xing)(xing)(xing)(xing)木器漆、工業(ye)涂(tu)(tu)料(liao)(liao)等場景(jing)；而(er)Texanol憑借強溶(rong)解力(li)和(he)(he)耐水(shui)(shui)(shui)性(xing)(xing)(xing)(xing)(xing)(xing)，更(geng)廣泛用(yong)于(yu)外墻涂(tu)(tu)料(liao)(liao)和(he)(he)溶(rong)劑(ji)(ji)(ji)型(xing)體(ti)系。**總結**：異(yi)(yi)(yi)己(ji)(ji)二(er)(er)醇(chun)(chun)(chun)(chun)(chun)(chun)在(zai)成(cheng)(cheng)(cheng)(cheng)膜(mo)(mo)(mo)(mo)均勻性(xing)(xing)(xing)(xing)(xing)(xing)、柔(rou)(rou)韌(ren)性(xing)(xing)(xing)(xing)(xing)(xing)和(he)(he)環(huan)(huan)保(bao)性(xing)(xing)(xing)(xing)(xing)(xing)上具有(you)優勢，但(dan)需(xu)(xu)(xu)平衡揮發速(su)率與(yu)耐水(shui)(shui)(shui)性(xing)(xing)(xing)(xing)(xing)(xing)。實際應(ying)用(yong)中(zhong)需(xu)(xu)(xu)根據樹脂(zhi)(zhi)體(ti)系、環(huan)(huan)境(jing)條件(jian)及性(xing)(xing)(xing)(xing)(xing)(xing)能(neng)(neng)需(xu)(xu)(xu)求(qiu)，與(yu)其(qi)(qi)(qi)(qi)他(ta)助(zhu)劑(ji)(ji)(ji)復(fu)配(pei)以優化綜(zong)合性(xing)(xing)(xing)(xing)(xing)(xing)能(neng)(neng)。

異己二醇（也被稱為2-甲(jia)基-2，4-或1，6-）的(de)(de)(de)(de)可燃(ran)(ran)(ran)性(xing)相(xiang)對(dui)較低。它是一(yi)種(zhong)含有(you)(you)兩(liang)個羥基的(de)(de)(de)(de)有(you)(you)機物，分子(zi)式為C6H14O2，具有(you)(you)特定(ding)的(de)(de)(de)(de)物理(li)和(he)化學(xue)性(xing)質(zhi)：熔點(dian)為-40℃，沸點(dian)達到(dao)198℃；閃(shan)點(dian)為97℃。雖然屬于可燃(ran)(ran)(ran)液體范疇內的(de)(de)(de)(de)一(yi)種(zhong)化學(xue)物質(zhi)，但由于其(qi)蒸(zheng)發(fa)速(su)率較低、不易揮發(fa)等特點(dian)在一(yi)定(ding)程(cheng)度(du)上降低了燃(ran)(ran)(ran)燒風(feng)險系數。然而值得注意(yi)的(de)(de)(de)(de)是當這種(zhong)物質(zhi)接觸到(dao)空(kong)氣(qi)、熱源和(he)火(huo)源等情(qing)況(kuang)(kuang)下仍(reng)然有(you)(you)可能發(fa)生(sheng)自燃(ran)(ran)(ran)或者事故(gu)因此在使用過程(cheng)中仍(reng)需(xu)格外小心謹慎處(chu)理(li)并嚴(yan)格遵守(shou)相(xiang)關(guan)安(an)全(quan)操作規程(cheng)以及(ji)儲(chu)存運輸管理(li)規定(ding)以確保(bao)人員和(he)環境的(de)(de)(de)(de)安(an)全(quan)不受威脅同時有(you)(you)效(xiao)(xiao)防止(zhi)火(huo)災及(ji)其(qi)他意(yi)外事故(gu)發(fa)生(sheng)造成(cheng)不必要(yao)損(sun)失(shi)和(he)影響。此外在存儲(chu)過程(cheng)中也要(yao)防潮防熱存放(fang)移(yi)除(chu)所有(you)(you)點(dian)火(huo)將容器(qi)密閉放(fang)置于干(gan)燥陰(yin)涼且(qie)通風(feng)狀(zhuang)況(kuang)(kuang)良好之處(chu)妥善保(bao)管好該化學(xue)品避免帶來安(an)全(quan)隱患(huan)問題產生(sheng)及(ji)擴散(san)蔓延趨勢(shi)發(fa)展下去影響更大范圍(wei)區域內部(bu)穩(wen)定(ding)性(xing)運行(xing)狀(zhuang)態(tai)正常進行(xing)過程(cheng)實現目標達成(cheng)預期效(xiao)(xiao)果等等一(yi)系列連鎖反應的(de)(de)(de)(de)發(fa)生(sheng)與發(fa)展進程(cheng)向前推進的(de)(de)(de)(de)速(su)度(du)加快(kuai)或是減(jian)緩情(qing)況(kuang)(kuang)的(de)(de)(de)(de)出現可能性(xing)存在與否的(de)(de)(de)(de)判斷(duan)依(yi)據條件是否充分滿足(zu)等問題都需(xu)要(yao)引起足(zu)夠重視(shi)并采(cai)取有(you)(you)效(xiao)(xiao)措施(shi)加以解決(jue)應對(dui)才行(xing)呢！